Arbloc Plus Drug Interactions

Losartan Potassium: Other drugs that block angiotensin II: Concomitant use of potassium-sparing diuretics (e.g. spironolactone, triamterene, amiloride), potassium supplements or salt substitutes containing potassium may lead to increase serum potassium.
Other antihypertensive agents: The antihypertensive effect of Losartan may be attenuated by the non-steroidal anti-inflammatory drug indomethacin.
Hydrochlorothiazide: Digitalis glycoside: May enhance the toxicity of diuretic-induced hypokalaemia.
Drugs that prolong the QT interval, such as astemizole, terfenadine, halofantrine, pimozide, and sotalol: May increase the risk of arrhythmias.
Neuromuscular blockers such as atracurium: May enhance the neuromuscular blocking action probably by hypokalaemic effect.
Corticosteroids, corticotropin, beta₂ agonists such as salbutamol, carbenoxolone, amphotericin B, or reboxetine: May enhance the potassium depleting effect of diuretics and hypertensive effects of diuretics may be antagonized by drugs that cause fluid retention, such as corticosteroids or carbenoxolone.
ACE inhibitors: Diuretics may enhance the effect of other antihypertensives, particularly the first dose hypotension that occurs with alpha blockers.
Alcohol, barbiturates, opioids: Orthostatic hypotension associated with diuretics may be enhanced.
NSAIDs: Cause fluid retention and may antagonize the diuretic actions of thiazides. Diuretics may enhance the nephrotoxicity of NSAIDs.
Noradrenaline: Thiazides have been reported to diminish the response to pressor amines, but the clinical significance of this effect is uncertain.
Lithium: the association may lead to toxic blood concentrations.
Antibacterials: Severe hyponatraemia has been reported in patients taking hydrochlorothiazide.
Antiepileptics: Symptomatic hyponatraemia has been reported if associated with hydrochlorothiazide and carbamazepine.
Bile-acid binding resins: Gastrointestinal absorption of hydrochlorothiazide has been reported to be reduced by colestipol and colestyramine. Colestyramine had the greatest effect on hydrochlorothiazide, decreasing absorption by 85% compared with a decrease of 43% with colestipol. Thiazides should be given ≥2 hours before the resin.
Dopaminergics: Increased amantadine toxicity associated with hydrochlorothiazide and triamterene.
Other drugs including allopurinol and tetracyclines: Increased toxicity has been reported when given with thiazides.
Thiazides: May alter the requirements for hypoglycaemics in diabetic patients.